We leave our marks on everything we touch. They are on the lenses of our glasses, on the keyboards we are working with, or on the door handles of our homes. Despite such omnipresent transfer of skin lipids, their removal is more complex. Cleaning materials are insufficiently wettable with lipids and additional detergents are urgently needed. Nevertheless, the development of specialized cleaning tools is possible and can be facilitated by dedicated surface characterizations applying contact angle measurements. As this approach is strongly dependent on the kind of soiling, the presented study concentrates on lipid-containing artificial skin and serves as exemplary application. For this purpose, insights are obtained by application of the Zisman model. As it describes the surface energy a liquid needs to spread completely on a solid, a comparison with the surface energy of the soiling is advisable. However, as not only the surface energy itself is of importance but the magnitudes of the individual surface energy components and corresponding molecular interactions are too, the Van Oss model is utilized. This differentiation between interactions gives important information about the underlying adhesion mechanism. If both models are combined, dedicated conclusions concerning an appropriate material are possible. Therefore, this application can potentially facilitate the development of specialized cleaning equipment.